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Unsuccessful Attempt to demonstrate a Paralytic Factor in Serum of Myasthenia Gravis Patients

Abstract

So far there has not yet been any clear confirmation of the experiments of Wilson and Stoner1, Adler2 and others which were thought to have demonstrated the presence of a curare-like substance in the serum of myasthenic patients. As the presence of such a circulating paralytic factor cannot explain the abnormal reaction of myasthenic patients when injected with decamethonium3, we thought it desirable to attempt further confirmation of the results obtained by Wilson and Stoner.

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References

  1. Wilson, A., and Stoner, H. B., Quart. J. Med., 13, 1 (1944).

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  2. Adler, H., Deut. Z. Chirurgie, 250, 614 (1938).

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  3. Zaimis, E. J., Churchill-Davidson, H. C., and Richardson, A. T., Nature, 170, 617 (1952).

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LAMMERS, W., VAN SPIJK, D. Unsuccessful Attempt to demonstrate a Paralytic Factor in Serum of Myasthenia Gravis Patients. Nature 173, 1192–1193 (1954). https://doi.org/10.1038/1731192b0

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