Abstract
THERE have been several reports in recent years suggesting that a blood coagulation factor other than factor VII or prothrombin may be affected by the administration of coumarin anticoagulant drugs. Dam (personal communication, 1952) has detected such a factor in his experimental work in chickens, and more recently Koller1 described a new factor, deficient in the blood of patients receiving coumarin anticoagulants, and unaffected by vitamin K.
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References
Koller, F., Communication to European Congress of Hæmatology, Amsterdam (1953).
Biggs, R., Douglas, A. S., and Macfarlane, R. G., J. Physiol., 119, 89 (1953). Biggs, R., and Douglas, A. S., J. Clin. Path., 6, 1, 23 (1953).
Hunter, R. B., and Walker, W., Communication to International Conference on Thrombosis and Embolism, Basle (1954).
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WALKER, W., HUNTER, R. Action of Coumarin Anticoagulants on a Possible New Serum Clotting Factor. Nature 173, 1192 (1954). https://doi.org/10.1038/1731192a0
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DOI: https://doi.org/10.1038/1731192a0
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