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Fractional Precipitation of Nucleic Acid

Nature volume 173, pages 1190–1191 (1954)Cite this article

Abstract

MELVILLE et al.1 have recently used turbidity measurements to follow the fractional precipitation of high polymers from solution. The turbid suspensions were found to be stable if very dilute polymer solutions were used. Nucleic acids are precipitated from aqueous solution by acids, cationic detergents, positively charged polyelectrolytes and alcohol. Stable suspensions are produced when hydrochloric acid solution is used as the precipitant for very dilute nucleic acid solutions, but the use of alcohol rapidly coagulates the precipitate. Solutions of cetyltrimethylammonium chloride give results similar to hydrochloric acid but the suspensions tend to flocculate near the end-point of the precipitation.

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References

  1. Melville, H. W., Dunn, A. S., and Stead, B. D., Trans. Farad. Soc. (in the press).

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Authors and Affiliations

  1. Department of Chemistry, University, Nottingham,

    A. R. MATHIESON & M. R. PORTER

Authors
  1. A. R. MATHIESON
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  2. M. R. PORTER
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MATHIESON, A., PORTER, M. Fractional Precipitation of Nucleic Acid. Nature 173, 1190–1191 (1954). https://doi.org/10.1038/1731190b0

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