Abstract
DURING the years 1934–45, a series of organic fluorides was prepared by Schrader1, and many of these compounds were found to be highly toxic to insects and to warm-blooded animals. More recent investigations have shown that the toxicity of some of these compounds, for example, the fluoroethanol and fluoroacetate derivatives, is due to interference with the oxidative processes in the cell2. The toxicity of the phosphorofluoridates, on the other hand, is due to inhibition of the true cholinesterase, and a subsequent accumulation of the acetylcholine released from nerve endings3. The sulphonyl fluorides and carbamoyl fluorides prepared by Schrader1 have not yet been extensively investigated.
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References
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MYERS, D., KEMP, A. Inhibition of Esterases by the Fluorides of Organic Acids. Nature 173, 33–34 (1954). https://doi.org/10.1038/173033a0
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DOI: https://doi.org/10.1038/173033a0
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