Abstract
PROFLAVINE (2-8 diamino acridinium sulphate, Abbott) in concentrations of 3–4 γ/ml. prevents liberation of infectious bacteriophage T2 from Escherichia coli, strain B, without preventing lysis1. The bacteria liberate incomplete non-infectious phage particles2. If proflavine is removed before lysis, the yield of complete phage is normal or subnormal. We have detected a mutagenic effect on phage produced in proflavine-treated bacteria.
Similar content being viewed by others
Article PDF
References
Fitzgerald, R. J., and Lee, M. E., J. Immun., 52, 127 (1946). Foster, R. A. C., J. Bact., 56, 795 (1948).
DeMars, R. I., Luria, S. E., Fisher, H., and Levinthal, C., Ann. Inst. Pasteur, 84, 113 (1953).
Hershey, A. D., Cold Spring Harb. Symposium Quant. Biol., 11, 67 (1946).
Luria, S. E., Cold Spring Harb. Symposium Quant. Biol., 16, 463 (1951).
Bertani, G., Genetics, 36, 598 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DEMARS, R. Chemical Mutagenesis in Bacteriophage T2. Nature 172, 964 (1953). https://doi.org/10.1038/172964a0
Issue Date:
DOI: https://doi.org/10.1038/172964a0
This article is cited by
-
Studies onr II region of T2-phage
Experientia (1968)
-
Mutagenit�tsuntersuchungen mit Trypaflavin und Hexamethylentetramin am S�uger in vivo und in vitro
Human Genetics (1967)
-
Transduction of resistance to cyanide
Folia Microbiologica (1960)
-
Increased Rate of Plaque-type and Host-range Mutation following Treatment of Bacteriophage in vitro with Ethyl Methane Sulphonate
Nature (1958)
-
Distribution of Proflavin-Induced Mutations in the Genetic Fine Structure
Nature (1958)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.