Abstract
THE distribution of enzymes within animal tissues has been studied most extensively in the case of liver. Particular interest has centred round the large granules (mitochondria), which have been found to contain the components of the cytochrome system, to catalyse the oxidation of all the citric acid cycle intermediates and the oxidation of fatty acids, and to carry out oxidative phosphorylation1. Recent work on cardiac muscle has shown that the particulate fraction (sarcosomes2) has a similar complement of respiratory enzymes and co-enzymes2,3; and there has been a tendency for sarcosomes to be considered identical with mitochondria. However, a large number of other enzymes are known to be associated with liver mitochondria, and it was of interest to investigate the distribution of one of these non-respiratory enzymes in cardiac muscle.
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References
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MOYLE, J. Intracellular Distribution of Rhodanese in Cardiac Muscle. Nature 172, 508–509 (1953). https://doi.org/10.1038/172508b0
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DOI: https://doi.org/10.1038/172508b0
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