Abstract
RECENT experiments have shown that compounds which affect acetylcholine metabolism can modify ion movement in a variety of tissues1. The locus of such drug effects can be better defined in the isolated frog skin, where it is possible to study quantitatively the active transport of sodium ions2.
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References
Rothenberg, M. A., Biochim. et Biophys. Acta, 4, 96 (1950). Holland, W., Dunn, C., and Greig, M., Amer. J. Physiol., 168, 546 (1952).
Ussing, H., “Advances in Enzymology”, 13, 21 (1952). Ussing, H., Zerahn, K., Acta Physiol. Scand., 23, 110 (1951).
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KIRSCHNER, L. Effect of Cholinesterase Inhibitors and Atropine on Active Sodium Transport across Frog Skin. Nature 172, 348–349 (1953). https://doi.org/10.1038/172348a0
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DOI: https://doi.org/10.1038/172348a0
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