Abstract
A NUMBER of substances are available to maintain the fluidity of blood outside the organism. It is usually assumed that the addition of the anticoagulants does not produce any change of the blood components involved in the clotting process. However, if after the addition of adequate quantities of citrate to blood, the cellular elements are removed and the calcium ion concentration is re-established in the separated plasma, then coagulation of the plasma will occur generally in a far shorter time than in blood which is allowed to clot without interference. It appears that some activation occurs during the isolation procedure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tocantins, L. M., and Carroll, R. T., Proc. Soc. Exp. Biol. N.Y., 69, 431 (1948).
Oettle, A. G., and Spriggs, A. I., “Recent Advances in Clinical Pathology”, 406 (2nd edit., London, 1951).
Dyckerhoff, Marx and Ludwig, Z. ges. Exp. Med., 110, 412 (1942).
Rosenfeld, G., and Janszky, B., Science, 116, 36 (1952).
Milstone, J. H., J. Gen. Physiol., 35, 67 (1951).
Ratnoff, O. D., and Conley, C. L., Johns Hopkins Hosp. Bull., 89, 245 (1951).
Quick, A. J., and Epstein, E., J. App. Physiol., 4, 840 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FANTL, P., HAYES, R. Formation of Thromboplastin in Shed Mammalian Blood. Nature 172, 303–304 (1953). https://doi.org/10.1038/172303b0
Issue Date:
DOI: https://doi.org/10.1038/172303b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
