Abstract
Murray and Clark1 have shown that, if red cells are heated to 50° C., substances can be obtained from the surrounding fluid which, even if derived from Rh-negative red cells, can give rise to anti-D agglutinins when injected into guinea pigs. Temperatures in the neighbourhood of 50°–56° produce extensive modifications of the human red-cell surface, namely, fragmentation, development of myelin forms, and, at the higher temperatures, hæmolysis2. It is therefore likely that the substances found by Murray and Clark in the fluid surrounding the heated cells are the products of the fragmentation phenomena and the changes in the red-cell surface which accompany them.
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References
Murray, J. M., and Clark, E. C., Nature, 169, 887 (1952).
Ponder, E., J. Exp. Biol., 26, 35 (1949); 27, 198 (1950).
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PONDER, R., PONDER, E. Agglutination Reactions in Human Red Cells Fragmented by Heat. Nature 170, 928 (1952). https://doi.org/10.1038/170928a0
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DOI: https://doi.org/10.1038/170928a0
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