Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Thalassaemia

Outcome of transplantation with unrelated donor bone marrow in children with severe thalassaemia

Bone Marrow Transplantation volume 33, pages 377–379 (2004)Cite this article

Summary:

We conducted a study of unrelated donor bone marrow transplantation (BMT) in 11 children with severe thalassaemia. The conditioning regimen consisted of busulphan, cyclophosphamide and antilymphocyte globulin. All received T-cell nondepleted bone marrow. The median marrow-nucleated cell dose was 4.9 × 108 /kg (range; 3.5−8.0 × 108 /kg). Median time of granulocyte recovery was 16 days (range; 13–21 days), and of platelet recovery was 39 days (range; 14–196). Grade 2–4 acute graft-versus-host disease (GVHD) developed in six patients (54%), and grade 3–4 in one patient (9%). Three (27%) of 11 evaluable patients had chronic GVHD (limited stage). All 11 patients are alive without thalassaemia after a median follow-up time of 397 days (range; 171–814 days). This study lends support to consideration of unrelated donor BMT as an acceptable therapy to cure severe thalassaemia especially in patients who are young and do not yet show irreversible severe complications of iron overload.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hongeng S, Krance RA, Bowman LC et al. Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukaemia. Lancet 1997; 350: 767–771.

    Article  CAS  Google Scholar 

  2. Davies SM, Kollman C, Anasetti C et al. Engraftment and survival after unrelated-donor bone marrow transplantation: a report from National Marrow Donor Program. Blood 2000; 96: 4096–4121.

    CAS  PubMed  Google Scholar 

  3. Contu L, La Nassa G, Arras M et al. Successful unrelated bone marrow transplantation in beta-thalassaemia. Bone Marrow Transplant 1994; 13: 329–331.

    CAS  PubMed  Google Scholar 

  4. Lucarelli G, Giardini C, Angelucci E . Bone marrow transplantation in thalassemia. In: Winter JN, (ed). Blood Stem Cell Transplantation. Kluwer Academic: Boston, MA, 1997, pp 305–315.

    Chapter  Google Scholar 

  5. Muretto P, Angelucci E, Del Fiasco S, Lucarelli G . Reversal features of hepatic haemosiderosis and haemochromatosis in thalassemia after bone marrow transplantation. Prog Clin Biol Res 1989; 309: 299–314.

    CAS  PubMed  Google Scholar 

  6. Hongeng S, Chuansumrit A, Hathirat P et al. Full chimerism in nonmyeloablative stem cell transplantation in a β-thalassemia major patient (class 3 Lucarelli). Bone Marrow Transplant 2002; 30: 409–410.

    Article  CAS  Google Scholar 

  7. Champlin RE, Schmitz N, Horowitz MM et al. Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation. Blood 2000; 95: 3702–3709.

    CAS  PubMed  Google Scholar 

  8. Gaziev D, Galimberti M, Lucarelli G et al. Bone marrow transplantation from alternative donors for thalassemia: HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplants. Bone Marrow Transplant 2000; 25: 815–821.

    Article  CAS  Google Scholar 

  9. Sullivan KM, Anasetti C, Horowitz M et al. Unrelated and HLA-nonidentical related donor marrow transplantation for thalassemia and leukemia. Ann NY Acad Sci 1998; 850: 312–324.

    Article  CAS  Google Scholar 

  10. La Nassa G, Giardini C, Argiolu F et al. Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypes. Blood 2002; 99: 4350–4356.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    S Hongeng, S Pakakasama, A Chuansumrit & N Sirachainan

  2. Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    A Ungkanont & S Jootar

  3. Bone Marrow Transplant Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    S Hongeng, S Pakakasama, W Chaisiripoomkere, A Chuansumrit, N Sirachainan, A Ungkanont & S Jootar

Authors
  1. S Hongeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Pakakasama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W Chaisiripoomkere
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Chuansumrit
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N Sirachainan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Ungkanont
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Jootar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S Hongeng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hongeng, S., Pakakasama, S., Chaisiripoomkere, W. et al. Outcome of transplantation with unrelated donor bone marrow in children with severe thalassaemia. Bone Marrow Transplant 33, 377–379 (2004). https://doi.org/10.1038/sj.bmt.1704361

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704361

Keywords

This article is cited by

Search

Advanced search

Quick links