Abstract
RECENT studies by Peters et al.1 have suggested that fluoroacetate poisoning is due to the formation in vivo of a fluorotricarboxylic acid which blocks the tricarboxylic acid cycle. In order to test this hypothesis, we have prepared sodium fluoroacetate labelled with carbon-14 in the methylene group.
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References
Liébecq, C., and Peters, R. A., Biochem. et Biophys. Acta., 3, 215 (1949). Buffa, P., Peters, R. A., and Wakelin, R. W., Biochem. J., 48, 467 (1951).
McCombie, H., and Saunders, B. C., Nature, 158, 382 (1946). Saunders, B. C., and Stacey, G. J., J. Chem. Soc., 1773 (1948).
Sanders, R. T., “Vacuum Manipulation of Volatile Compounds”, 90 (1948).
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SAUNDERS, B., WORTHY, T. Preparation of Carbon-labelled Sodium Fluoroacetate on a Micro-scale. Nature 169, 38–39 (1952). https://doi.org/10.1038/169038a0
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DOI: https://doi.org/10.1038/169038a0
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