Abstract
SOME years ago it was suggested that the first step in melanogenesis, the oxidation of tyrosine to o-dihydroxyphenylalanine, can be represented by the following general reactions: (1) o-dihydroxyphenol → o-quinone → intermediate products → melanin; (2) o-quinone + monohydroxyphenol + H2O = 2 o-dihydroxyphenol; and that of these reactions only the first is really enzymic1.
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KERTÉSZ, D. Tyrosinase and Polyphenoloxidase; the Role of Metallic Ions in Melanogenesis. Nature 168, 697 (1951). https://doi.org/10.1038/168697a0
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DOI: https://doi.org/10.1038/168697a0
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