Abstract
Erythrocytic fragmentation, produced by the incessant buffeting in the circulation, has been considered by several authors1,2 to be the most important factor in the destruction of erythrocytes. This fragmentation was thought to be much increased in thalassæmia major (Cooley's anæmia), where poikilocytosis and schizocytosis are very evident3–5. Nevertheless, there are few experimental records of mechanical fragmentation in vitro.
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TOLENTINO, P. Mechanical Fragility of Thalassæmic Erythrocytes. Nature 167, 905 (1951). https://doi.org/10.1038/167905a0
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DOI: https://doi.org/10.1038/167905a0
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