Abstract
At a meeting of the Biometric Society in March 1950 1, one of us (E.C.W.) presented a paper on the analysis of biological assays when there is replication of doses within litters. In that paper, and in the subsequent discussion, we both strongly upheld the view that the calculation of the fiducial limits to the estimate of relative potency must be based upon a mean square from the doses × litters interaction in the analysis of variance, and not upon the intra-litter mean square. This appeared to follow by analogy with the accepted practice for tests of significance in the analysis of experiments.
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References
Gridgeman, N. T., Nature, 165, 843 (1950).
Jerne, N. K., and Wood, E. C., Biometrics, 5, 273 (1949).
Fieller, E. C., Quart. J. Pharm. and Pharmacol., 17, 117 (1944).
Burn, J. H., Finney, D. J., and Goodwin, L. G., “Biological Standardization”, 83 (1950).
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FINNEY, D., WOOD, E. Intra-Litter Replication in Biological Assays. Nature 167, 903–904 (1951). https://doi.org/10.1038/167903a0
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DOI: https://doi.org/10.1038/167903a0
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