Abstract
IN a recent communication1, I described a new colour reaction for the antithyroid drugs, 2-thiouracil and 4-methyl-2-thiouracil. This is based upon the yellow colour which is given when small concentrations of the drugs are treated with 2 : 6-dichloro-quinone-chloroimide at pH 8.0. Although some free amino-acids, purines and other urinary solutes give coloured products in the reaction, these latter are insoluble in chloroform, whereas within certain concentration limits the coloured products of the reaction with the drugs are readily extractable from the aqueous phase by this solvent. By this means the colour reaction has been made specific, and has been applied to the colorimetric determination of methyl-thiouracil in urine.
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References
McAllister, R. A., Nature, 166, 789 (1950).
Stanley, M. M., and Astwood, E. B., Endocrin., 44, 588 (1949).
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McALLISTER, R. Colour Reaction for Certain Mercaptoimidazoles. Nature 167, 863 (1951). https://doi.org/10.1038/167863a0
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DOI: https://doi.org/10.1038/167863a0
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