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Separation of the Optical Antipodes of Racemic β-Naphthol Benzylamine by Paper Chromatography

Abstract

THE difficulties found by several investigators1 in attempting to separate a racemic compound into its optical antipodes by means of chromatography on paper are well known. We have attempted to resolve organic racemic bases into their optical isomers, using the method of partition on chromatographic paper, and the results obtained with racemic β-naphthol benzylamine are reported in the present communication.

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References

  1. Dent, C. E., Biochem. J., 43, 169 (1949). Zechmeister, L., “Stereochemistry and Chromatography”, Ann. New York Acad. Sci., 49, 220 (1949). Lederer, E., “Progrès recents de la Chromatographie”, 37 (Paris: Herman, 1949). Flood, A. B., Hirst, E. L., and Jones, J. K. N., J. Chem. Soc., 1679 (1948).

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BONING, G., CARASSITI, V. Separation of the Optical Antipodes of Racemic β-Naphthol Benzylamine by Paper Chromatography. Nature 167, 569–570 (1951). https://doi.org/10.1038/167569a0

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