Abstract
DURING the course of investigations on the effect of the various œstrogenic hormones on the reticulo-endothelial system, it was noted that many animals showed toxic effects. The relative toxicity of the various œstrogens was therefore investigated. Such toxic effects of natural and synthetic œstrogens have been studied in various laboratory animals by many workers1–7, who noted hepatic and renal damage and anaplastic anæmia in animals treated with large daily doses of œstrogens. Castrodale et al.4 observed in dogs some fatty degeneration and central necrosis in the liver, and MacBryde et al.7 noted that the changes in the liver parenchyma were not widespread and consisted of fatty and hydropic degenerations, which were produced equally by all œstrogens used (œstrone, œstradiol benzoate, and diethylstilbœstrol dipropionate).
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NICOL, T., HELMY, I. Toxicity of Œstrogens. Nature 167, 321 (1951). https://doi.org/10.1038/167321a0
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DOI: https://doi.org/10.1038/167321a0
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