Abstract
TRAUB1 appears to have elaborated a killed vaccine capable of evoking an effective immunity against swine erysipelas. It consists essentially of formalin-killed bacterial cells and other antigenic substances present in liquid cultures precipitated by means of aluminium hydroxide gel. However, he does not give his method in sufficient detail to enable it to be faithfully repeated. Nevertheless, he emphasizes that: (1) only certain strains of E. rhusiopathiæ are able to produce active vaccine; (2) vaccine activity is dependent upon the precipitation both of the bacterial cells, and of a soluble antigen present in the medium. An efficient vaccine immunizes mice in doses of 0.2 ml. after dilution 1/16, 1/64 or even 1/256 in aluminium hydroxide gel. It also immunizes pigs against experimental infections produced by the method of Fortner and Dinter2 and has given satisfactory results in the field3.
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References
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Fortner, J., and Dinter, Z., Z. Infektions-Krankh. Haustiere, 60, 157 (1944).
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GLEDHILL, A. Immunization against Erysipelothrix rhusiopathiæ with Killed Vaccine. Nature 166, 952 (1950). https://doi.org/10.1038/166952a0
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DOI: https://doi.org/10.1038/166952a0
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