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A New Powerful Blood Anticoagulant

Abstract

IN an effort to elucidate the mechanism of reaction of di(4-hydroxycoumarinyl-3)acetie acid, called by us ‘pelentanic acid’, in boiling acetanhydride1 (I), we prepared di(4-hydroxycoumarinyl-3)propanone by condensation of two molecules of 4-hydroxycoumarin with one molecule of isonitrosoacetone in a water solution (II).

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References

  1. Fučíkt, K., Procházka, Ž., and Čechová, V., Bull. soc. chim., 16, 99 (1949); Chem. listy, 43, 49 (1949).

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  2. Reiniš and Kubík, Schw. med. Wochenschrift, 785 (1948).

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FUČÍK, K., PROCHÁZKA, Ž., LÁBLER, L. et al. A New Powerful Blood Anticoagulant. Nature 166, 830–831 (1950). https://doi.org/10.1038/166830a0

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  • DOI: https://doi.org/10.1038/166830a0

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