Abstract
TRAINA1 has reported that intraperitoneal injections of vitamin B12 prevent histamine shock following the intracardiac administration of histamine to guinea pigs. Antagonism between histamine and vitamin B12 might be of importance in the assay of histamine in liver extracts, and we accordingly investigated this relationship. We have tried to repeat Traina's work, and have also studied the effect of prior administration of vitamin B12 on the reduction of arterial blood pressure in the cat after intravenous injection of histamine.
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References
Traina, V., Nature, 165, 439 (1950).
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SHARPE, H., WOOLLETT, E. & CUTHBERTSON, M. Vitamin B12 and Antihistamine Activity. Nature 166, 651–652 (1950). https://doi.org/10.1038/166651a0
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DOI: https://doi.org/10.1038/166651a0
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