Abstract
DURING an investigation of the antiproteolytic properties of polysaccharide polysulphuric acids, including heparin, the action of these substances was tested on hyaluronidase, as representing a depolymerizing enzyme differing from the proteolytic enzymes. The viscosity determinations were carried out as described by Lundquist1. They were recorded with the logarithm of the time of flow (in sec.) as the ordinate. The heparin was a commercial product (Løvens Kemiske Fabrik, Copenhagen) and the polysulphuric acids were prepared as previously described2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lundquist, F., Acta Physiol. Scand., 17, 44 (1949).
Astrup, T., Galsmar, I., and Volkert, M., Acta Physiol. Scand., 8, 215 (1944). Astrup, T., and Piper, J., Acta Physiol. Scand., 9, 351 (1945).
McClean, D., J. Path. Bacteriol., 54, 284 (1942).
Bergamini, L., Boll. Ist. Sieroterap. Milan, 27, 115 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ASTRUP, T., ALKJÆRSIG, N. Polysaccharide Polysulphuric Acids as Antihyaluronidases. Nature 166, 568–569 (1950). https://doi.org/10.1038/166568b0
Issue Date:
DOI: https://doi.org/10.1038/166568b0
This article is cited by
-
Mucosaccharides and glycoproteins
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie (1959)
-
Enzyme Inhibition
Nature (1954)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.