Abstract
THE configuration of the C/D ring fusion in equilenin has been the subject of a number of communications1–3. We consider that the arguments advanced for a trans ring junction leave much to be desired. Shoppee's1 conclusion that the dehydrogenation of equilin to equilenin under mild conditions proves the steric identity of the C/D union in these two substances can no longer be accepted, since isoequilin, which is now known4,5 to be also trans, gives isoequilenin (which has the opposite C/D configuration to equilenin) under the same conditions6.
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References
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STORK, G., SINGH, G. Configuration of the C/D Ring Junction in Equilenin and Other Steroids. Nature 165, 816 (1950). https://doi.org/10.1038/165816a0
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DOI: https://doi.org/10.1038/165816a0
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