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Liberation of Heparin and Histamine by d-Tubocurarine

Nature volume 165, pages 320–321 (1950)Cite this article

Abstract

IT is well known that curare1 and tubocurarine2 liberate histamine from skeletal muscle. I have perfused the isolated lungs of the guinea pig as described by Feldberg and Kellaway3, and find that tubocurarine chloride (B. W. and Co.) in doses of 1–10 mgm. liberates histamine, the output of which resembles in magnitude and time that caused by injury by peptone or anaphylaxis.

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References

  1. Alam, M., Anrep, G. V., Barsoum, G. S., Talaat, M., and Wieninger, E., J. Physiol., 95, 148 (1939).

    Article  CAS  Google Scholar 

  2. Schild, H. O., and Gregory, R. A., Proc. XVII Int. Physiol. Congr., 288 (1947).

  3. Feldberg, W., and Kellaway, C. H., J. Physiol., 90, 259 (1937).

    Google Scholar 

  4. Kellaway, C. H., Edin. Med. J., 54, 333 (1947).

    CAS  Google Scholar 

  5. Jacques, L. B., and Waters, E. T., J. Physiol., 99, 454 (1941).

    Article  Google Scholar 

  6. MacIntosh, F. C., and Paton, W. D. M., J. Physiol., 109, 140 (1949).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University of Melbourne,

    G. REID

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  1. G. REID
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REID, G. Liberation of Heparin and Histamine by d-Tubocurarine. Nature 165, 320–321 (1950). https://doi.org/10.1038/165320a0

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