Abstract
IT is often said that the different corticosteroids have qualitatively different activities. Desoxycorticosterone is believed to act only on electrolyte metabolism, while 11-dehydro-17-hydroxycorticosterone (compound E) acts on glycogen production. This view is based mainly on results with methods of bio-assay in which adrenalectomized rats on a high-protein diet are given divided doses of these corticosteroids over a period of six hours; two hours after the last injection, liver glycogen is estimated1–3.
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References
Olson, R. E., Thayer, S. A., and Kopp, L. J., Endocrin., 35, 464 (1944).
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Sass-Kortsák, A., Wang, F. C., and Verzár, F., Amer. J. Physiol., 159, 256 (1949).
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WANG, F. Glycogen Production from Glucose with Desoxycorticosterone and 11-Dehydro- 17-hydroxycorticosterone. Nature 165, 277–278 (1950). https://doi.org/10.1038/165277a0
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DOI: https://doi.org/10.1038/165277a0
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