Abstract
THE production of agglutinating and precipitating antisera in rabbits is normally a slow, painstaking process requiring numerous intravenous inoculations. This is especially true of streptococcal antisera. Inoculation of the antigen in a bland excipient which would be slowly enough absorbed to create a constant immunizing process would obviate the necessity for these repeated intravenous inoculations. I believe that calcium alginate fulfils this requirement.
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References
Lancefield, Rebecca C., J. Exp. Med., 57, 571 (1933).
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SLAVIN, D. Production of Antisera in Rabbits using Calcium Alginate as an Antigen Depot. Nature 165, 115–116 (1950). https://doi.org/10.1038/165115a0
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DOI: https://doi.org/10.1038/165115a0
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