Abstract
IT was shown in a series of papers from this Laboratory that desoxycorticosterone has in vitro, in the concentration of 1–5 mgm. per cent, an inhibitory effect on glycogen formation1– 4 of the isolated muscle, which has since been explained as a glycogenolytic action5. This was the more unexpected since it seems certain that this adrenal cortical steroid has in the intact animal a distinct glyco-genetic action6–8. We therefore tried whether it might be possible to reverse also the glycogenetic activity of desoxycorticosterone in the intact animal by increasing the dose to an inhibitory or glycogenolytic one.
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References
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VERZÁR, F., WANG, F. Reversal of Glycogenetic to Glycogenolytic Action of Desoxycorticosterone in Rats. Nature 165, 114–115 (1950). https://doi.org/10.1038/165114a0
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DOI: https://doi.org/10.1038/165114a0
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