Abstract
IN a recent publication1, we reported a considerable purification (approximately 2,500-fold) of the toxic factor from zein treated with nitrogen trichloride, which gives rise to convulsive fits in rabbits. As recorded, the best preparations were contaminated to an unknown extent with free amino-acids—proline, methionine and, as it now appears, probably histidine. Reiner et al.2 and Butler and Mills3 have also concentrated the toxic factor ; but the degree of purification attained appears to be considerably less than that reported by us earlier1.
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References
Bentley, H. R., McDermott, E. E., Pace, J., Whitehead, J. K., and Moran, T., Nature, 163, 675 (1949).
Reiner, L., Weiss, P., Misani, F., Cordasco, M. G., and Fair, T. W., Fed. Proc., 8, 230 (1949).
Butler, J. A. V., and Mills, G. L., Nature, 163, 835 (1949).
Synge, R. L. M., Biochem., J., 44, 542 (1949).
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BENTLEY, H., MCDERMOTT, E., PACE, J. et al. Action of Nitrogen Trichloride ('Agene') on Proteins: Isolation of Crystalline Toxic Factor. Nature 164, 438–439 (1949). https://doi.org/10.1038/164438a0
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DOI: https://doi.org/10.1038/164438a0
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