Abstract
HISTAMINE is released from tissues in anaphylaxis, by trypsin, peptones, snake poisons, curare and diamidines. Garan1 has shown that ammonia vapour liberates histamine from guinea pigs' lungs. The following experiments show that histamine is quantitatively released from striated muscle in a solution of ammonium chloride, but that the effect is entirely dependent on pH, suggesting that it is produced by the free base.
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Change history
16 July 1949
An Erratum to this paper has been published: https://doi.org/10.1038/164099f0
References
Garan, R. S., Arch. Exp. Path. Pharmak. 188, 250 (1938).
Rocha e Silva, M., and Schild. H. O., J Physiol. (in the press).
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SCHILD, H. Release of Histamine by Ammonia. Nature 164, 24–25 (1949). https://doi.org/10.1038/164024b0
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DOI: https://doi.org/10.1038/164024b0
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