Abstract
GONADOTROPHINS resemble blood-group specific substances in several respects. Meyer1 has classified these compounds together as neutral mucoids ; Bussard and Eyquem2 claim to have demonstrated a serological relationship between blood-group substances and chorionic gonadotrophin. McShan and Meyer3 have observed inactivation of gonadotrophins by human saliva, whereas Schiff and Akune4 found that this material destroyed blood-group A substance. In addition, it has been shown that blood-group substances5,6 and serum gonadotrophin7 are substrates of the receptor-destroying enzyme produced by Vibrio choler" and of the similar enzymic component of influenza virus. It would appear, then, that gonadotrophins and blood-group substances have a similar structure and may be inactivated by the same enzymes. This hypothesis was further examined by studying the action on serum gonadotrophin of enzymes which decompose blood-group specific substances.
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References
Meyer, K., "Advances in Protein Chemistry", 2, 249 (1945).
Bussard, A., and Eyquem, A., Ann. Inst. Pasteur, 73, 1194 (1947).
McShan, W. H., and Meyer, R. K., J. Biol. Chem., 126, 367 (1938).
Schiff, F., and Akune, M., Munch, med. Wschr., 78, 657 (1931).
Burnet, F. M., McCrea, J. F., and Anderson, S. G., Nature, 160, 404 (1947).
Burnet, F. M., Aust. J. Sci., 19, 21.
Whitten, W. K., Aust. J. Sci. Res. (in the press).
Morgan, W. T. J., Nature, 158, 759 (1946).
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WHITTEN, W. Enzymic Inactivation of Serum Gonadotrophin. Nature 163, 534 (1949). https://doi.org/10.1038/163534a0
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DOI: https://doi.org/10.1038/163534a0
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