Abstract
IT has been shown by Lodge and Hinshelwood1 that when a basal glucose-ammonium medium is inoculated with bacteria from a similar medium, the lag period which develops depends upon the age of the inoculating cells. If the latter were transferred early in their logarithmic phase of growth, a considerable lag period might develop which the authors termed 'early lag' and which they attributed to the diffusion from the cells of the metabolic intermediates necessary for rapid cell division to commence ; sterile filtrates from fully grown cultures were able, for example, to effect a removal of this lag period because they supplied the cells with relatively high concentrations of the intermediates.
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References
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DAGLEY, S., DAWES, E. & MORRISON, G. Application of Bacterial Kinetics to Biochemical Problems. Nature 163, 532–533 (1949). https://doi.org/10.1038/163532b0
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DOI: https://doi.org/10.1038/163532b0
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