Abstract
IT is well known that alcoholic or aqueous extracts of central nervous tissues (especially brain) lower the arterial blood pressure when injected intravenously into laboratory animals (dogs, cats, rabbits, etc.)1,2,3. The chemical agent, or agents, of the pressor effect, however, have not yet been identified ; studies by Vincent et al.3, Major and Weber1 and more recently Kwiatkowski4 having apparently discarded (or greatly minimized) the role of both histamine and choline in the pharmacological activity of the extracts. The object of this note is to present evidence that histamine is the main agent responsible for the depressor effect, and that central nervous system tissues, therefore, as well as many other tissues (liver, lung, skin, muscle, etc.)5, contain histamine.
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CICARDO, V., STOPPANI, A. Presence of Histamine in Central Nervous System Extracts. Nature 163, 365 (1949). https://doi.org/10.1038/163365a0
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DOI: https://doi.org/10.1038/163365a0
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