Abstract
TEN guinea pigs (of medium weight, 350 gm.) were sensitized with 1/10 c.c. of horse serum by intraperitoneal injection. After fifteen days, two of them, used as controls, Were given 1 c.c. of the same sensitizing serum directly into the heart ; both died. Another guinea pig was given, intramuscularly, 15 mgm. of folic acid ten minutes before receiving the same dose of serum by intracardiac injection. This guinea pig also died of anaphylactic shock. Six others were given 30 mgm. of folic acid by intraperitoneal injection (to accelerate absorption), and the same serum treatment fifteen minutes later. All of them survived. Finally, the last guinea pig Was given 15 mgm. of folic acid intraperitoneally and the same serum treatment after fifteen minutes. This one survived, too, but showed slight symptoms of shock.
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References
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TRAINA, V. Folic Acid as an Anti-anaphylactic. Nature 163, 364–365 (1949). https://doi.org/10.1038/163364c0
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DOI: https://doi.org/10.1038/163364c0
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