Abstract
PREVIOUS communications1,2 have recorded the synthesis of antibacterial compounds derived from bile acids and sterols which contained basic groups, such as the amino-, amidino- and guanido-groups. In general, these derivatives were bacteriostatic for Gram-positive bacteria, but had little activity against Gram-negative organisms. Whereas surface tension measurements seemed to reveal a relationship between the bacteriostatic and surface activities of the bile acids and their anionic derivatives3, no such relationship was apparent in the properties of a series of the basic steroid compounds4. In an extension of these studies, we have synthesized and investigated several water-soluble, sulphur-containing, steroid derivatives.
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References
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JONES, A., SMITH, F. & WEBB, M. Sulphur-containing Steroid Derivatives. Nature 162, 857–858 (1948). https://doi.org/10.1038/162857b0
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DOI: https://doi.org/10.1038/162857b0
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