Abstract
FOUR nucleosides—guanosine, adenosine, cytidine and uridine—are formed in the hydrolysis of yeast ribonucleic acid by aqueous pyridine, and Bredereck et al.1 have described a method of isolating the nucleosides from the hydrolysate. Although this method is adequate for the production of guanosine and adenosine, we have been unsuccessful in isolating the pyrimidine nucleosides in the pure state and in good yield by this method, and believe this to be due to the method of isolation adopted by Bredereck.
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Bredereck, H., Martini, A., and Richter, F., Ber. Deut. chem. Ges., 74 B, 694 (1941).
Levene, P. A., and Simms, H. S., J. Biol. Chem., 65, 519 (1925).
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ELMORE, D. Separation of Pyrimidine Nucleosides by Synthetic Resin Ion-Exchangers. Nature 161, 931 (1948). https://doi.org/10.1038/161931a0
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DOI: https://doi.org/10.1038/161931a0
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