Abstract
THE usual method of preparing heparin, due to Charles and Scott1, involves rough extraction of tissues with alkali and subsequent tryptic digestion of the protein precipitate.
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References
Charles, A. F., and Scott, D. A., J. Biol. Chem., 102, 425 (1933).
Palmer, J. W., Smyth, E. M., and Meyer, K., J. Biol. Chem., 119, 507 (1937).
Sylvén, B., Acta chir. scand., 86, Suppl. 66 (Stockholm, 1941).
Jaques, L. B., and Charles, A. F., Quart. J. Pharm. and Pharmacol., 14, 1 (1941).
Jorpes, J. E., "Heparin in the Treatment of Thrombosis" (Oxford Univ. Press, sec. edit., 1946).
Wilander, O., Skand. Arch. f. Physiol., 81, Suppl. 15 (Berlin, 1938).
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SNELLMAN, O., JENSEN, R. & SYLVÉN, B. A New Extraction Procedure for the Preparation of Heparin. Nature 161, 639 (1948). https://doi.org/10.1038/161639a0
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DOI: https://doi.org/10.1038/161639a0
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