Abstract
ONE of us recently directed attention1 to the 'radiomimetic' action of hydroquinone. In the intestine of the mouse, extensive nuclear destruction, occurring before the onset of prophase in the cells of the germinative region, was observed four hours after an injection of 0·125 mgm./gm. The interest taken in this type of mitotic poisoning has been increased by the description by Mitchell and Simon-Reuss2 of the synergic effects of X-rays and a vitamin K substitute (diphosphoric ester of methylnaphthoquinone) on mitosis in normal and cancerous tissues. Naphthoquinone is known to be a mitotic poison3. A further investigation of the cytological disturbances following the injection of various quinone and phenolic compounds has led to the observation in the small intestine of the mouse of a new type of abnormal mitosis.
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References
Dustin, P., jun., Nature, 159, 794 (1947). Zylberszac, S., Acta brevia néerl., 9, 240 (1939).
Mitchell, J. S., and Simon-Reuss, I., Nature, 160, 98 (1947).
Lehmann, F. E., and Hadorn, H., Helv. Physiol. Pharm. Acta, 4, 11 (1946). Meier, R., and Allgöwer, M., Experientia, 1, 57 (1945). Meier, B., and Schär, B., Experientia, 3, 358 (1947).
Hegner, R. W., J. Morph., 25, 375 (1914).
Moellendorff, W. v., Z. Zellf., 27–32 (1937–1943).
Lea, D. E., "Action of Radiations on Living Cells" (Cambridge University Press, 1946). Politzer, G., "Pathologie der Mitose" (Gebr. Borntraeger, Berlin, 1934).
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PARMENTIER, R., DUSTIN, P. Early Effects of Hydroquinone on Mitosis. Nature 161, 527–528 (1948). https://doi.org/10.1038/161527a0
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DOI: https://doi.org/10.1038/161527a0
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