Abstract
IT was shown by Krebs1 that the energy required for the synthesis of glutamine from glutamic acid and ammonia which occurs in tissue slices of brain cortex, can be furnished by the oxidation of glucose. In the course of a more general investigation of phosphate-transferring enzymes, evidence has been obtained that adenosinetriphosphate is the immediate energy donor for glutamine synthesis. Since this work was performed, Speck, in a recent publication2, has reported similar results obtained from work on glutamine synthesis in pigeon liver.
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References
Krebs, H. A., Biochem. J., 29, 1951 (1935).
Speck, J. F., J. Biol. Chem., 168, 403 (1947).
Lipmann, F., and Tuttle, L. C., J. Biol. Chem., 159, 21 (1945).
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ELLIOTT, W. Adenosinetriphosphate in Glutamine Synthesis. Nature 161, 128–129 (1948). https://doi.org/10.1038/161128a0
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DOI: https://doi.org/10.1038/161128a0
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