Abstract
THE Kapeller-Adler1 method for the estimation of phenylalanine depends on the nitration of phenylalanine to give 3:4 dinitrophenylalanine; this is then reduced by alkaline hydroxylamine to a coloured nitroso derivative. It appeared probable that, by virtue of its phenylacetic radical, penicillin II (G) might be estimated in the same way and in the presence of penicillin I (F).
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References
Kapeller-Adler, R., Biochem. Z., 252, 185 (1932).
Hess, W. C., and Sullivan, M. X., Arch. Biochem., 5, 165 (1944).
Bratton, A. C., and Marshall, E. K., J. Biol. Chem., 128, 537 (1939).
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PAGE, J., ROBINSON, F. Colorimetric Estimation of Penicillin II. Nature 158, 910–911 (1946). https://doi.org/10.1038/158910b0
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DOI: https://doi.org/10.1038/158910b0
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