Abstract
IT is not possiblein a short article to mention all the types of substances, organic and inorganic in character, active in vitro, which have been tested against tuberculosis experimentally induced in animals. One encouraging fact emerges from the . early work however. Certain substances, tuberculoeidal or tuberculostatic in character, have been shown to have the power of penetrating the tubercle in vivo. It has not been shown, on the other hand, that any substances congregate selectively in tuberculous tissue or that their concentration in this tissue will remain at a high level while falling in the blood. All that can be truly said is that access to the desired site of action of the drug is apparently possible to some substances, although the action of these substances in vito my not be reproduced in the tubercle in the living animal.
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BARRY, V. Anti-Tubercular Compounds. Nature 158, 863–865 (1946). https://doi.org/10.1038/158863a0
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DOI: https://doi.org/10.1038/158863a0
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