Abstract
IT has been observed that the use of human serum, instead of saline, as a diluent in titration of immune agglutinins (A, B, Rh) enhances the action of these antibodies, and higher titres are therefore obtained1. Similarly, the “conglutination-test” for the detection of Rh sensitization is also based on the use of human serum, instead of saline, for dilution in titration2. In describing the “conglutination-reaction”, Wiener suggested that this is due to a serum factor, a protein, which is not fully developed in the foetus and is formed only shortly after delivery2,3. The post-natal formation of sufficient quantities of this protein would presumably account for the development of erythroblastosis talis after delivery, and not during pregnancy.
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References
Boorman, K. E., Dodd, B. E., and Morgan, W. I. J., Nature, 156, 663 (1945).
Wiener, A. S., J. Lab. and Clin. Med., 30, 662 (1945).
Wiener, A. S., Amer. J. Diseas. Child., 71, 14 (1946).
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POLISHUK, Z., GUREVITCH, J. Enhancement of Immune Antibodies by Human Serum. Nature 158, 589–590 (1946). https://doi.org/10.1038/158589c0
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DOI: https://doi.org/10.1038/158589c0
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