Abstract
IN an interesting communication in Nature1, Prof. Lacroix has reviewed his investigations of an osteogenetic substance which can be extracted from the bone tissue with alcohol, and for which he proposes the name osteogenin. We should like, however, to point out that this substance has already been reported by Levander2, Annersten3 and Bertelsen4. We are at present engaged in a more detailed investigation of its chemical nature. In experiments performed in collaboration with Dr. Hans Bohr, we have confirmed Annersten's finding that the osteogenetic substance can be shaken out from its alcoholic solution with benzene. Furthermore, by saponiflcation we have divided the lipid substances in the bone marrow into (a) the unsaponifiable fraction, (b) the fatty acid fraction and (c) the residual solution after saponification and extraction of (a) and (b). The osteogenetic activity in (a) was very low, that in (b) somewhat higher, while fraction (c) was completely inactive. The investigation is being continued.
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References
Nature, 156, 576 (1945).
Surg. Gynecol. Obst., 67 (1938). Nature, 155, 148 (1945).
Acta Chirurg. Scand., 84, Suppl. 60 (1940).
Acta Orthoped. Scand., 15, 139 (1945).
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LEVANDER, G., WILLSTAEDT, H. Alcohol-Soluble Osteogenetic Substance from Bone Marrow. Nature 157, 587 (1946). https://doi.org/10.1038/157587b0
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DOI: https://doi.org/10.1038/157587b0
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