Abstract
IT is generally understood that, in the action of carboxylase on pyruvic acid or other allied keto acics, carbon dioxide is directly split off. The following experiments show that this is not so, but that carbonic acid is first formed, the process contrasting with urease action in which carbon dioxide is directly produced in the splitting of urea. (This latter has been investigated by Roughton and Krebs1 with respect to the action of carbonic anhydrase, and the present study of carboxylase is suggested by their procedure.)
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References
Roughton, F. J. W., Physiol. Rev., 15, 263 (1935).
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CONWAY, E., MACDONNELL, E. Carboxylase and Carbonic Acid. Nature 156, 752–753 (1945). https://doi.org/10.1038/156752a0
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DOI: https://doi.org/10.1038/156752a0
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