Abstract
PALUDRINE, or 4888 as it was first called, the new drug for malaria, which was announced at the annual meeting of the Liverpool School of Tropical Medicine on November 5, was discovered in the laboratories of I.C.I, at Blackley, Manchester. The chemical work was directed by Dr. F. H. S. Curd and Dr. F. L. Rose, and the biological work by Dr. D. G. Davey. The substance has two outstanding points of scientific interest. First, it marks a complete departure in chemical structure from the known antimalarial drugs; it is not a quinoline like quinine and pamaquin, and it is not an acridine like mepacrine—an account of it, together with its constitution, will be given in papers which will appear shortly in the Annals of Tropical Medicine and Parasitology. Secondly, in avian malaria it has a powerful action not only on the blood forms of the parasite, but also on the so-called exoerythrocytic forms. The latter are now known to occur in almost every type of avian malaria, and it is the working hypothesis of the I.C.I, group of workers, as it is of some others, that these forms also exist in human malaria although they have never been demonstrated microscopically.
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Paludrine: a New Anti-malarial Drug. Nature 156, 596–597 (1945). https://doi.org/10.1038/156596c0
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DOI: https://doi.org/10.1038/156596c0