Abstract
RATS fed on diets containing thiourea and thiouracil die after varying periods of time. Some preliminary experiments showed that in the case of rats on 0·5 per cent thiourea, the action of the drug was reversible up to a certain stage; but after this, death occurred whether the animals were put back on to the control diet or not. This indicated that thiourea was exerting more than a simple antithyroid effect. Hughes1 found similar results with thiouracil. We also observed in rats on both thiourea and thiouracil that in the terminal stages (the last two days) the suprarenals were frequently enlarged and dark reddish brown in colour. Except in the terminal stages, however, our findings confirm those of Williams, Weinglass, Bissell and Peters2, who reported that in rats treated with thiouracil the suprarenals were smaller than normal although the ratio of gland-weight to body-weight was normal.
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References
Hughes, A. M., Endocrinol., 34, 69 (1944).
Williams, R. H., Weinglass, A. R., Bissell, G. W., and Peters, J. B., Endocrinol., 34, 317 (1944).
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GLOCK, G. Thiourea and the Suprarenal Cortex. Nature 156, 508 (1945). https://doi.org/10.1038/156508a0
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DOI: https://doi.org/10.1038/156508a0
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