Abstract
THE action of penicillin on leishmania infections has not so far been reported in the literature. This note deals with the treatment of four hamsters infected with an Indian strain of the parasite which has previously been employed by me in chemotherapeutic tests1. The methods used were the same as those already described. The Golden Hamster (Cricetus auratus) is the most suitable animal for experimental studies of this infection, since in their case the disease, so far as is known, never shows spontaneous regression and finally causes death. The in vitro action of penicillin on tissue forms of the parasite and on flagellate forms in young and old cultures is also described. Thanks are due to the Penicillin Clinical Trials Committee of the Medical Research Council for a supply of material.
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References
Fulton, J. D., Ann. Trop. Med. and Parasitol., 38, 147 (1944).
Bigger, J. W., Lancet, 247, 497 (1944).
Garrod, L. P., Brit. Med. J., 107 (Jan. 27, 1945).
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FULTON, J. Penicillin in Leishmania Infections. Nature 156, 203 (1945). https://doi.org/10.1038/156203a0
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DOI: https://doi.org/10.1038/156203a0
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