Abstract
THE well-known rapid absorption of penicillin when it is given subcutaneously or intramuscularly and its rapid disappearance from the blood and excretion by the kidneys was mentioned in an earlier article (Nature, 677, Nov. 25, 1944). J. H. Humphrey (Nature, 765, Dec. 16, 1944) concluded from a study of two cases of abortion with extreme oliguria that, when there is no significant renal excretion of penicillin, it is slowly inactivated in the body. Sir Alexander Fleming (Lancet, 620, Nov. 11, 1944) describes, with illustrations, the micro-methods which he has devised for the estimation of penicillin in the blood serum and other body fluids. In the same issue of the Lancet (p. 621) Sir Alexander Fleming, M. Y. Young, J. Suchet and A. J. E. Rowe record their work on the penicillin content of the blood serum after various doses have been given subcutaneously, intravenously and intramuscularly, either as single injections or by continuous drip.
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LAPAGE, G. Absorption, Excretion and Local Application of Penicillin. Nature 155, 341–342 (1945). https://doi.org/10.1038/155341a0
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DOI: https://doi.org/10.1038/155341a0