Abstract
THE methylation of pyridine in the animal body was observed by His1. When he showed that pyridine was converted to N-methyl pyridinium hydroxide and when Ackermann2 found that ingested nicotinic acid was partly eliminated as trigonelline, these observations were at that time mainly of theoretical interest. They became of practical value, however, when nicotinamide was shown to be a constituent of the coenzymes I and II by Warburg and Christian3, Warburg, Christian and Griese4, and v. Euler, Albers and Schlenk5, and their significance became obvious when Knight6 demonstrated the importance of nicotinic acid as a growth factor in bacteria, and Elvehjem, Madden, Strong and Woodley7 showed the curative effect of nicotinic acid in canine black tongue and suggested its identity with Goldberger's PP factor; this fact was verified by numerous investigators. It was of considerable interest, therefore, when Najjar and Wood8 published their discovery that a whitish blue fluorescent substance was present in the urine of normal subjects and was increased in amount after the ingestion of nicotinamide and other related compounds.
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ELLINGER, P. Nicotinamide Methochloride and Its Fluorescent Derivatives. Nature 155, 319–322 (1945). https://doi.org/10.1038/155319a0
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DOI: https://doi.org/10.1038/155319a0
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