Abstract
THE finding of Shaw-Dunn and co-workers1 that alloxan (and a styryl-quinoline) causes diabetes by damaging the pancreatic islet cells has since been amply confirmed in a number of laboratories, working with various animal species. Attempts to discover other substances with similar action have so far been unsuccessful, nor has any explanation been offered regarding the mechanism by which alloxan attacks the β-islet cells.
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References
Shaw-Dunn, J., Sheehan, H. L., and McLetchie, N. G. B., Lancet, 244, 484 (1943).
Jacobs, H. R., Proc. Soc. Exp. Biol. Med., 37, 407 (1937).
Goldner, M. G., and Gomori, G., Endocrinology, 35, 241 (1944).
Thorogood, C., Federation Proc., 3, 48 (1944).
Strecker, A., Ann. Chem., 123, 363 (1862).
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BRÜCKMANN, G., WERTHEIMER, E. Diabetogenic Action of Alloxan Derivatives. Nature 155, 267–268 (1945). https://doi.org/10.1038/155267b0
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DOI: https://doi.org/10.1038/155267b0
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