Abstract
RECENTLY, we have reported a series of findings showing partial blockage of the anterior hypophysis in rat and fowl by prolonged treatment with œstrogenic hormone1,2. In these experiments it proved possible to eliminate growth hormone and gonadotrophic hormone by treatment with œstrogens, and as a result eunuchoid dwarf rats and similarly impaired chickens could be produced. Growth was found to be inhibited by the treatment to 60 per cent in the rat and to 30 per cent in the fowl. Inhibition was marked when large doses of œstrogens were given for a longer period.
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References
Zondek, B., Lancet, 230, 10, 776 and 842 (1936).
Zondek, B., Fol. Clin. Orient., 1, 1 (1937).
Deanesly, R., and Parkes, A. S., Proc. Roy. Soc., B, 124, 279 (1937).
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Zondek, B., "Clin. and Exp. Investigations on the Genital Functions and their Hormonal Regulation", 145 (Baltimore: Williams and Wilkins, 1941).
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ZONDEK, B. Stimulation of the Anterior Hypophysis by Œstrogenic Hormone. Nature 154, 154–155 (1944). https://doi.org/10.1038/154154a0
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DOI: https://doi.org/10.1038/154154a0
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