Abstract
Promin Treatment of Leprosy IN a recent paper (Public Health Rep., 58, 1729; 1943) G. H. Paget, R. C. Pogge, F. A. Johansen, J. F. Dinan, B. M. Prejean and C. G. Eccles of the United States Marine Hospital (National Leprosarium), Carville, La., record their observations on the treatment of leprosy by promin, the sodium salt of p.p.diaminodiphenyl-sulphone-n.n.didœstrose sulphonate in a paper based on the study of forty-six cases. Their conclusions are as follow. (1) Promin is the sulphon-amide drug which so far seems to possess to the greatest' extent some chemotherapeutic properties against leprosy. (2) While no direct evidence of a specific bacteriostatio or bactericidal-action against M. leprce has been demonstrated, it has been observed that promin seems capable of inhibiting* the progress of leprosy in a considerable number of cases. (3) Promin can be safely administered intravenously for prolonged periods provided the blood and urine are examined frequently. Toxic manifestations, of whichhæmolysis is the most important, are relatively few and mild. (4) Further experimental and clinical studies on the treatment of leprosy with promin are required before more definite conclusions can be drawn.
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Research Items. Nature 153, 465–466 (1944). https://doi.org/10.1038/153465a0
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DOI: https://doi.org/10.1038/153465a0